AlphaFold Redesigned Gene-Editing Proteins, Reducing Error Risk

Researchers used AI protein-folding software AlphaFold to identify key areas in gene-editing proteins responsible for off-target effects, then modified those areas to reduce errors. This approach aims to improve the safety of gene-editing therapies.

Gene-editing systems face safety challenges due to off-target effects, where the wrong DNA sequence is edited. Researchers used AlphaFold, an AI protein-folding software, to identify key regions of Cas proteins responsible for these errors. By modifying those regions, they reduced off-target effects, potentially improving the safety of gene-editing therapies. The study was published in Nature.

Сокращения: RNA = Ribonucleic Acid — Рибонуклеиновая кислота; DNA = Deoxyribonucleic Acid — Дезоксирибонуклеиновая кислота

Source: Ars Technica — original